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    BoneKEy Webinar Archives
    The progression of dormant disseminated breast cancer to bone metastasis
    Date:

    IBMS BoneKEy is pleased to announce the twelth IBMS BoneKEy Webinar to take place on Tuesday, 19 March 2012 from 12:00 noon to 1 PM Eastern (U.S.) Standard Time (5 pm-6 pm UK time zone/6 pm-7 pm Central European time zone).

    Description:

    Discuss key research and clinical applications:

    • How do we model clinical dormancy and reactivation in experimental mouse models?
    • What are the molecular drivers that promote the activation of indolent bone micrometastasis?
    • How do we prevent the activation of dormant tumor cells?
    • Key questions for future research.

    Powerpoint and audio will be available shortly.

    The IBMS BoneKEy Webinar is a free, live, online web conference where a hot topic is presented by an expert in the field and a discussion by panelists follows.

    Expert Presenter
    Yibin Kang
    Princeton University, USA
    Moderator

    Philippe Clezardin IBMS BoneKEy Associate Editor INSERM, Lyon, France

    Non-invasive Evaluation of Bone Microarchitecture and Strength
    Date:

    IBMS BoneKEy is pleased to announce the twelth IBMS BoneKEy Webinar to take place on Tuesday, 21 February  2012 from 12:00 noon to 1 PM Eastern (U.S.) Standard Time (5 pm-6 pm UK time zone/6 pm-7 pm Central European time zone).

    Description:

    Review the available techniques for non-invasive assessment of bone structure in humans

    Discuss key research and clinical applications:

    • Understanding changes in growth and aging
    • Gender differences
    • Identification of patients at risk of fracture
    • Assessing response to therapy

    Powerpoint and audio will be available shortly.

    The IBMS BoneKEy Webinar is a free, live, online web conference where a hot topic is presented by an expert in the field and a discussion by panelists follows.

    Expert Presenter
    Sundeep Khosla
    Mayo Clinic College of Medicine, Rochester MN
    Panelists
    • Elizabeth Shane (Columbia University, College of Physicians and Surgeons, NY, NY)
    • Sharmila Majumdar (University of California, San Francisco, San Francisco, CA)
    • Stephanie Boutroy (INSERM, Université de Lyon, Lyon, France)
    • Tony Keaveny (University of California, Berkeley, Berkeley, CA)
    • Claus-C. Glüer (Medizinische Physik, Klinik für Diagnostische Radiologie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany)
    Moderator

    Serge Ferrrari, Geneva University Hospital, Geneva Switzerland

    Multiple Myeloma Bone Disease: Novel Insights into Pathogenesis and Management

    Date:
    IBMS BoneKEy is pleased to announce the eleventh IBMS BoneKEy Webinar to take place on Tuesday, January 17, 2012 from 12:00 noon to 1 PM Eastern (U.S.) Standard Time (5 pm-6 pm UK time zone/6 pm-7 pm Central European time zone

    Description:

     A live 20 minute online presentation, complete with PowerPoint slides, followed by panel discussion and audience questions, will address these questions:

    • What are the current guidelines for the management of multiple myeloma bone disease?
    • How can the field take advantage of new advances in the biology of multiple myeloma bone disease for the treatment of multiple myeloma patients?
    • Is there a role for denosumab in the treatment of multiple myeloma bone disease?
    • Can bone-anabolic drugs be used in this setting?

    CLICK HERE FOR THE POWERPOINT PRESENTATION AND AUDIO

    The IBMS BoneKEy Webinar is a free, live, online web conference where a hot topic is presented by an expert in the field and a discussion by panelists follows.

    Expert Presenter
    Evangelos Terpos, M.D., Ph.D.
    University of Athens School of Medicine, Athens, Greece

    Invited Panelists
    Massimo Massaia (Centro di Ricerca in Medicina Sperimentale (CeRMS) and Ospedale San Giovanni Battista di Torino e Universita’ degli Studi di Torino); G. David Roodman (Indiana University School of Medicine)

    Moderator

    Philippe Clézardin, Ph.D. (INSERM, University of Lyon, Lyon, France)

     

    The Role of Phosphatases in the Initiation of Skeletal Mineralization

    The tenth IBMS BoneKEy Webinar on The Role of Phosphatases in the Initiation of Skeletal Mineralization will take place on Friday, December 16, 2011 from 12:00 noon to 1 PM Eastern (U.S.) Daylight Time (9 am-10 am Pacific (U.S.) time zone/5 pm-6 pm UK time zone/6 pm-7 pm Central European time zone)

    The IBMS BoneKEy Webinar is a free, live, online web conference where a hot topic is presented by an expert in the field and audience questions/discussion follow.

    CLICK HERE FOR THE POWERPOINT PRESENTATION AND AUDIO

    Expert Presenter
    Jose Luis Millán, Ph.D.
    Sanford-Burnham Medical Research Institute, La Jolla, CA, USA

    A live, 40-minute online presentation, complete with PowerPoint slides, followed by audience questions/discussion, will discuss the role of phosphatases (alkaline phosphatase, NPP1 and PHOSPHO1) in the initiation of skeletal mineralization; discuss diseases such as hypophosphatasia (HPP) and medial vascular calcification, which are caused by low and high alkaline phosphatase expression, respectively; and discuss therapeutic approaches.

    Moderator
    Larry J. Suva, Ph.D.
    University of Arkansas for Medical Sciences, Little Rock, AR, USA

    A recording of the webinar will be available soon. Stay tuned.

    The Role of Phosphatases in the Initiation of Skeletal Mineralization is supported by a grant from:

    Enobia

     

    Disseminated and Circulating Tumor Cells: Their Detection and Clinical Significance
    The ninth IBMS BoneKEy Webinar on Disseminated and Circulating Tumor Cells: Their Detection and Clinical Significance took place on Tuesday, October 18, 2011 from 12:00 noon to 1 PM Eastern (U.S.) Daylight Time (5 pm-6 pm UK time zone/6 pm-7 pm Central European time zone)
     

    CLICK HERE FOR THE POWERPOINT PRESENTATION AND AUDIO

    The IBMS BoneKEy Webinar is a free, live, online web conference where a hot topic is presented by an expert in the field and a discussion by panelists follows.

    Expert Presenter
    Klaus Pantel, M.D., Ph.D.

    University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    A live 20 minute online presentation, complete with PowerPoint slides, will address the detection of disseminated tumor cells (DTCs) and circulating tumor cells (CTCs) as a diagnostic tool for cancer patients, as well as the prognostic relevance and clinical significance of these cells in the cancer setting.

    Invited Panelists
    Evi Lianidou
    University of Athens
    Jean-Yves Pierga
    Institut Curie and Université Paris Descartes
    Moderator
    Philippe Clézardin, Ph.D.
    INSERM, University of Lyon, Lyon, France

     

    The Management of Bone Fragility/Low Bone Mass in Children and Adolescents

    The eighth IBMS BoneKEy Webinar on The Management of Bone Fragility/Low Bone Mass in Children and Adolescents took place on Tuesday, June 14th, 2011 from 12:00 noon to 1 PM Eastern (U.S.) Daylight Time (5 pm-6 pm UK time zone/6 pm-7 pm Central European time zone)

    CLICK THIS LINK FOR THE POWERPOINT PRESENTATION AND AUDIO

    CLICK HERE FOR A NEWS SUMMARY OF THE WEBINAR

    The IBMS BoneKEy Webinar is a free, live, online web conference where a hot topic is presented by an expert in the field and a discussion by panelists follows.

    Expert Presenter
    Catherine M. Gordon, M.D.
    Children's Hospital Boston, Boston, MA, USA

    A live 20 minute online presentation, complete with PowerPoint slides, will discuss:

    • Identifying risk factors for a low bone density among children and adolescents
    • Measurement tools that are available to evaluate bone health in a pediatric population
    • Management strategies for the care of those children identified to have a low bone mass and/or skeletal fragility
    Invited Panelists
    Maria Luisa Bianchi
    Istituto Auxologico Italiano, IRCCS, Milan, Italy
    Nick Bishop
    University of Sheffield, Sheffield, UK
    Joseph A. Janicki
    Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Craig Munns
    The Children's Hospital at Westmead, Westmead, Australia
    Leanne M. Ward
    University of Ottawa, Ottawa, Ontario, Canada
    Moderator
    Craig B. Langman, M.D.
    Feinberg School of Medicine, Northwestern University, and Children's Memorial Hospital, Chicago, IL, USA

     

    The Potential Anti-cancer Activity of Bisphosphonates in the Clinic

    The seventh IBMS BoneKEy Webinar on The Potential Anti-cancer Activity of Bisphosphonates in the Clinic took place on Wednesday, May 25, 2011 from 12:00 noon to 1 PM Eastern (U.S.) Daylight Time (5 pm-6 pm UK time zone/6 pm-7 pm Central European time zone)

    CLICK HERE FOR THE POWERPOINT PRESENTATION AND AUDIO

    CLICK HERE for NEWS summary of the Webinar!

    The IBMS BoneKEy Webinar is a free, live, online web conference where a hot topic is presented by an expert in the field and a discussion by panelists follows.

    Expert Presenter
    Robert Coleman, M.D.
    University of Sheffield, Sheffield, United Kingdom

    A live 20 minute online presentation, complete with PowerPoint slides, will address these questions:

    • Do bisphosphonates have anti-cancer activity in the clinical setting?
    • What are the underlying mechanisms of action. In particular, what is the rationale for adjuvant bisphosphonates in breast cancer - Is the vicious cycle clinically relevant?
    • What is the evidence of anti-cancer activity from clinical trials? In particular, the webinar will provide an overview of published clinical trial results in early breast cancer, as well as new findings from AZURE, a trial in 3360 women with early breast cancer
    • How might reproductive hormones be influencing the bone microenvironment and efficacy of adjuvant bisphosphonates?
    • What are the key outstanding issues for future research?
    Invited Panelists
    Peyman Hadji
    Philipps-University of Marburg
    Evangelos Terpos
    University of Athens School of Medicine
    Moderator
    Philippe Clézardin, Ph.D.
    INSERM, University of Lyon, Lyon, France

     

    Bisphosphonates and Atypical Femoral Fractures: What Should Clinicians Know and Do?

    The sixth IBMS BoneKEy Webinar, "Bisphosphonates and Atypical Femoral Fractures: What Should Clinicians Know and Do?", took place on Monday, April 18, 2011 from 12:00 noon to 1 PM Eastern (U.S.) Daylight Time (5 pm-6 pm UK time zone/6 pm-7 pm Central European time zone)

    CLICK THIS LINK FOR THE POWERPOINT PRESENTATION AND AUDIO

    CLICK HERE for a NEWS summary of the Webinar!

    The IBMS BoneKEy Webinar is a free, live, online web conference where a hot topic is presented by an expert in the field and a discussion by panelists follows.

    Expert Presenter
    Juliet E. Compston, M.D.

    University of Cambridge School of Clinical Medicine, Cambridge, UK

    A live 20 minute online presentation, complete with PowerPoint slides, followed by a panel discussion, will address these questions:

    • What are the characteristics of atypical femoral fractures, and how do these fractures differ from more typical osteoporotic fractures?
    • What is the incidence of atypical femoral fractures?
    • What is the relationship between duration of bisphosphonate use/cumulative bisphosphonate dose and risk of atypical femoral fractures?
    • Is there a typical patient at risk for atypical femoral fractures?
    • How should clinicians identify and report atypical femoral fractures?
    • What should clinicians do regarding patients who have been on bisphosphonates for more than five years?
    Invited Panelists
    David B. Burr
    Indiana University School of Medicine
    Fergus E. McKiernan
    Marshfield Clinic
    Elizabeth Shane
    Columbia University
    Larry J. Suva
    University of Arkansas for Medical Sciences)
    Moderator
    Serge Ferrari, M.D.
    Geneva University Hospital, Geneva, Switzerland

     

     

    Osteoimmunology: T Cells, RANKL, and Beyond

    The fifth IBMS BoneKEy Webinar on Osteoimmunology: T Cells, RANKL, and Beyond took place on Wednesday, December 8, 2010 from 12:00 noon to 1 PM EST.

    CLICK THIS LINK FOR THE POWERPOINT PRESENTATION AND AUDIO

    CLICK HERE for a NEWS summary of the Webinar

    The IBMS BoneKEy Webinar is a free, live, online web conference where a hot topic is presented by an expert in the field and a discussion by panelists follows.

    Expert Presenter
    Roberto Pacifici, M.D.
    Emory University School of Medicine, Atlanta, Georgia

    A live 20 minute online presentation, complete with PowerPoint slides, will address these questions:

    • Is postmenopausal bone loss an inflammatory disorder of bone? What is the respective contribution of estrogen deficiency directly on osteoclasts, and indirectly through T cell activation?
    • What is the role of RANKL in T cell/dendritic cell activation and subsequent bone loss? Could RANKL inhibitors inhibit bone loss also by modulating T cell/dendritic cell interactions?
    • What is the evidence that RANKL inhibitors affect immune/inflammatory functions?
    • What is the contribution of T cell-expressed costimulatory molecules and T cell/stromal cell cross-talk to postmenopausal bone loss?
    Invited Panelists
    Pierrick Fournier
    Indiana University School of Medicine
    Sundeep Khosla
    Mayo Clinic
    Steven L. Teitelbaum
    Washington University School of Medicine
    M. Neale Weitzmann
    Emory University School of Medicine
    Moderator
    Serge Ferrari, M.D.
    Geneva University Hospital, Geneva, Switzerland

     

    Osteoimmunology: T Cells, RANKL, and Beyond is supported by a grant from:

    Amgen

    The Clinical Potential of Genetic Markers of Osteoporosis

    The fourth IBMS BoneKEy Webinar on The Clinical Potential of Genetic Markers of Osteoporosis took place on Tuesday, September 21, 2010 from 12:00 noon to 1 PM EDT.

    CLICK THIS LINK FOR THE POWERPOINT PRESENTATION AND AUDIO

    CLICK HERE for a NEWS summary of the Webinar!

    The IBMS BoneKEy Webinar is a free, live, online web conference where a hot topic is presented by an expert in the field and a discussion by panelists follows.

    Expert Presenter
    Tim Spector, M.D.
    King's College, London, UK
    • A live 20 minute online presentation, complete with PowerPoint slides, will address these questions:
    • Where does the bone field now stand with regard to osteoporosis risk genes?
    • What have we learned from genomewide association studies (GWAS)?
    • How much of fracture risk can be explained by genetic variants identified thus far?
    • Are we targeting the right genetic markers?
    • How can genetic approaches in humans and in mice be combined in a fruitful way?
    • What does the future look like: should the bone field focus on studying much larger numbers of people, or functional markers instead?
    Invited Panelists
    Cheryl Ackert-Bicknell
    The Jackson Laboratory
    Cecile Janssens
    Erasmus University Medical Center
    David Karasik
    Institute for Aging Research, Hebrew SeniorLife
    Joseph Zmuda
    University of Pittsburgh)
    Moderator
    Serge Ferrari, M.D.
    Geneva University Hospital, Geneva, Switzerland)

     

    When to Treat Bone Fragility, 2010: FRAX® and Beyond

    The third IBMS BoneKEy Webinar on When to Treat Bone Fragility, 2010: FRAX® and Beyond took place on Tuesday, February 16, 2010 from noon to 1 PM EDT

    CLICK THIS LINK FOR THE POWERPOINT PRESENTATION AND AUDIO

    CLICK HERE for a NEWS summary of the Webinar!

    The IBMS BoneKEy Webinar is a free, live, online web conference where a hot topic is presented by an expert in the field and a discussion by panelists follows.

    Expert Presenter
    John A. Kanis, M.D.
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, UK

    A live 20 minute online presentation, complete with PowerPoint slides, whose goal is to:

    • Compare and contrast intervention thresholds in Europe and the US based on current guidelines for osteoporosis management in these regions
    • Discuss how to best determine intervention thresholds
    • Discuss which intervention threshold is the most appropriate at various ages
    • Discuss whether fracture probability according to FRAX® should override the T-score to determine whom to treat, and discuss practical cases where fracture probability according to the T-score and FRAX® might differ
    • Discuss the need to improve the FRAX® tool, and summarize ongoing development in this regard
    Invited Panelists
    Steven R. Cummings
    University of California, San Francisco
    Adolfo Diez-Perez
    Autonomous University of Barcelona
    Eugene McCloskey
    University of Sheffield
    Michael R. McClung
    Oregon Osteoporosis Center)
    Moderator
    Serge Ferrari, M.D.
    Geneva University Hospital, Geneva, Switzerland)
    Biological and Pharmacological Effects of Estrogen and SERMs on Bone

    The second IBMS BoneKEy Webinar on Biological and Pharmacological Effects of Estrogen and SERMs on Bone took place on Tuesday, April 21, 2009 from noon to 1 PM EDT.

    CLICK HERE for a NEWS summary of the Webinar!

    The IBMS BoneKEy Webinar is a free, live, online web conference where a hot topic is presented by an expert in the field and a discussion by panelists follows.

    Expert Presenter
    Donald P. McDonnell, Ph.D
    Duke University Medical School, Durham, NC, USA

    A live 20 minute online presentation, complete with PowerPoint slides:

    • Molecular mechanisms and pharmacology of estrogen and SERM signaling
    • Effects of estrogen and SERMs on osteoblasts and osteoclasts
    • Effects of estrogen and SERMs on remodeling of bone surfaces
    • Clinical effects of raloxifene and new SERMs on bone
    Invited Panelists
    Roger Bouillon
    Katholieke Universiteit Leuven, Leuven, Belgium
    Steven R. Cummings
    University of California, San Francisco, San Francisco, CA, USA
    Luigi Gennari
    University of Siena, Siena, Italy
    Robert Lindsay
    Helen Hayes Hospital and Columbia University, New York, NY, USA
    Stavros Manolagas
    University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Claes Ohlsson
    University of Gothenburg, Gothenburg, Sweden
    Moderator
    Serge Ferrari, M.D.
    Geneva University Hospital, Geneva, Switzerland

    Biological and Pharmacological Effects of Estrogen and SERMs on Bone is supported by an unrestricted educational grant from:

    Wyeth

     

    "Postoperative Management of Hip Fractures”

    The inaugural IBMS BoneKEy Webinar on Postoperative Management of Hip Fractures took place on Tuesday, October 14, 2008 from noon to 1 PM EST. The Webinar was a great success: 32 attendees listened to an online PowerPoint presentation by expert presenters Douglas P. Kiel and Sarah D. Berry and an ensuing discussion by an esteemed group of panelists.

    CLICK THIS LINK FOR THE POWERPOINT PRESENTATION AND AUDIO

    CLICK HERE FOR A NEWS SUMMARY OF THE WEBINAR

    Expert Presenters
    Douglas P. Kiel, M.D., M.P.H. and Sarah D. Berry, M.D., M.P.H.
    The Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA

    A live 20 minute online presentation, complete with PowerPoint slides:

    • There is a theoretical risk that bisphosphonates would impair fracture healing. What do the animal studies tell us?
    • What is the optimal time to start postoperative bisphosphonates?
    • Many studies have documented undertreatment of osteoporosis after hip fracture. What is a useful approach to getting treatment to patients?
    • How do interventions to prevent falls figure into one's approach to a patient with a hip fracture?
    • Case series have reported femoral shaft fractures in bisphosphonate-treated patients with low bone turnover; the overall risk appears to be very low. Were such fractures seen in the Horizon study? Is the risk of such fractures increased in the post-fracture setting? Can we identify a subset of patients at increased risk of complications?
    • How should we approach vitamin D therapy for fall prevention and fracture protection post hip fracture?
    • The data on fracture protection by hip protectors are decidedly mixed. How can we get to an answer regarding their role in high-risk patients?
    Invited Panelists
    Michael R. McClung
    Oregon Osteoporosis Center, Portland, OR, USA
    Kenneth W. Lyles
    Duke University Medical Center, Durham, NC, USA
    Cathleen Colon-Emeric
    Duke University Medical Center, Durham, NC, USA
    David Marsh
    University College London, London, UK
    Fergus E. McKiernan
    Marshfield Clinic, Marshfield, WI, USA
    Joseph E. Zerwekh (University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA)
    Moderator
    Gordon J. Strewler, M.D.
    Harvard Medical School, Boston, MA, USA

    "Postoperative Management of Hip Fractures" is supported by an unrestricted educational grant from:

    Novartis

    International Bone and Mineral Society (IBMS)
    330 N Wabash, Suite 1900, Chicago, IL 60611 - USA
    Phone: +1 312-321-5113   |   Fax: +1 312-673-6934   |   Email: