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Sunday, August 1, 2010 AM: Issues in Modern Histomorphometry – 50 Years Later  

1. Overview of Issues (R. Recker, Creighton University)
2. Histomorphometry in translational research (D. Kimmel, Merck and Co.)
3. Remodeling oversuppression and the handling of missing and single labels (D. Dempster, Helen Hayes Hospital)
4. The meaning and measurement of activation frequency and erosion depth (R. Weinstein, University of Arkansas) 
5. Panel Discussion: (Drs. Recker, Dempster, Wronski, Weinstein, and Kimmel) 

Sunday Afternoon (2:00pm - 4:00pm)
Volleyball at Sun Valley Lake! Refreshments provided!
This is a great place to get acquainted with other participants on a very informal basis. Even if you don't play volleyball, stop by for some refreshments and conversation. EVERYONE WELCOME!  

• Differences in Strength and Structure among Ape and Human Thoracic Vertebrae
  Meghan Cotter (Case Western Reserve University)
• Heterozygous Disruption of Gsα in Osteocytes Decreases Peripheral Fat without Affecting Bone Mass
  Keertik Fulzele (Massachusetts General Hospital)
• Additive Effect of Type 2 Diabetes Mellitus on Estrogen Depletion-induced Bone Changes in Female ZDSD Rats
  Maxime Gallant (IU School of Medicine)
• The Effect of Polyethylene Particles in a Rat Model of Femoral Implantation
  Shuo Liu (Rush University Medical Center)
• RANKL and OPG Activity is Regulated by Injury Size in Networks of Osteocyte-like Cells
  Lauren Mulcahy (Royal College of Surgeons in Ireland)
• The Impact of Type 2 Diabetes on Bone Microarchitecture: A Cross-sectional Evaluation in Postmenopausal Women
  Janet Pritchard (McMaster University)
• TITLE TBD
  Ling Qin (University of Pennsylvania)
• Alternative Splicing in Bone Following Mechanical Loading
  Sara Mantila Roosa (Purdue University)
• Direct Local Measures of Mineral Apposition Rate in 3D
  Craig Slyfield (Cornell University)
• Mechanical Loading Stimulates Localized Bone Adaptation in the Mouse Tibia
  Karen Lindsay Troy (University of Illinois at Chicago)

1. Overview (J. Hannafin, Hospital for Special Surgery)
2. Insights into clinical and biological aspects of tendon biology, mechanics and repair (J. Hannafin, HSS)
3. Molecular differentiation of tendons: scleraxis and Mohawk transcription factors (R. Schweitzer, University of Oregon)
4. Recent advances in mechanotransduction and where we stand in tendon  (A. Banes, University of North Carolina)
5. Rabbit tendon stem cells for repair and regeneration (J. Wang, University of Pittsburgh)

• Cx43 Deletion in Osteocytes Results in Cortical Osteocyte Apoptosis, Periosteal Expansion and Reduced Bone Material Stiffness
  Nicoletta Bivi (Indiana University of School of Medicine)
• A Phe377del Mutation in ANK Leads to Impaired Osteoblastogenesis and Osteoclastogenesis in a Mouse Model for Craniometaphyseal Dysplasia (CMD)
  I-Ping Chen (University of Connecticut Health Center)
• The Role of the GH/IGF 1 Axis in Regulating Musculoskeletal Development
  Douglas DiGirolamo (Johns Hopkins University)
• Identification of Novel Vitamin D Receptor Target Genes based on Promoter Interaction with the Vitamin D Response Element Binding Protein
  Thomas Lisse (University of California at Los Angeles, Orthopaedic Hospital Research Center)
• Skeletal Effects of Glucocorticoids and Selective Glucocorticoid Receptor Agonists
  Martina Rauner (Dresden University Medical Center)
• Intermittent PTH Treatment Increases Intracortical Microporosities in Ovariectomized Rats
  Steven Tommasini (SUNY-Stony Brook)

1. NMR measurement of bone quality (D. Nicolella, Southwest Research Institute)
2. Raman spectroscopic measures of bone quality and function (M.Morris, University of Michigan)
3. Probing alterations in bone structure and composition in osteoporosis using synchrotron-based imaging (L. Miller, Brookhaven National Laboratory)
4. Changes in bone structure during growth and aging (S.Khosla, Mayo Clinic)
5. Bone material properties are different in patients with and without fractures. (P. Hansma, University of California, Santa Barbara)
6. Clinical application of the bone microindentation test (Adolfo Diez Perez, Autonomous University of Barcelona, Barcelona)

1. Overview of the interaction of various biological pathways with fluid shear (C. Jacobs, Columbia University)
2. The interaction of the PTH receptor and mechanical signals in bone cells (J. Frangos, La Jolla Bioengineering Institute)
3. Sclerostin mode of action (M. Kneissel)
4. The role of sclerostin and the Wnt pathway in mediating the effects of mechanical loading (A. Robling, Indiana University)

1. Introduction to epigenetics and its translational potential (A. van Wijnen, University of Massachussetts)
2. Runx2-dependent architectural epigenetics and control of osteoblast proliferation (A. van Wijnen, University of Massachussetts)
3. Biological role of the histone deacetylase HDAC3 to skeletal development (J. Westendorf, Mayo Clinic)
4. Deficiency in the methylated DNA binding protein Mecp2 and skeletal defects related to Rett syndrome (C. Schanen, Nemours Biomedical Research, Alfred DuPont Hospital for Children)